Teriparatide,PTH1-34,hPTH(1-34),Humanparathyroidhormone-(1-34) , 98% , 52232-67-4

Synonym(s):
Parathormone (1-34);Parathyroid Hormone 1-34, Human - CAS 52232-67-4 - Calbiochem;PTH 1-34;Teriparatide

CAS NO.：52232-67-4

Empirical Formula: C172H278N52O47S2

Molecular Weight: 3890.5

MDL number: MFCD00149013

EINECS: 640-978-1

PRODUCT Properties

• Melting point: >205oC (dec.)
• RTECS: SQ7770000
• storage temp.: −20°C
• solubility: DMSO (Slightly), Water (Slightly)
• form: powder
• color: White to Off-White
• Water Solubility: Soluble to 0.40 mg/ml in water
• Sequence: H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH
• Stability: Hygroscopic
• CAS DataBase Reference: 52232-67-4(CAS DataBase Reference)

Description and Uses

The anabolic drug teriparatide acetate (TA), known as recombinant human parathyroid hormone 1–34, which directly promotes bone formation by generating new osteocytes, has been introduced as a novel therapeutic agent for osteoporosis. Distinct from antiresorptive drug treatment, patients with osteonecrosis of the jaw showed successful clinical outcomes after weekly administration of TA. In addition, adverse outcomes of long-term bisphosphonate treatment, such as bone fracture, were healed after usage of TA, and better bone mass and mineral density improvements at the lumbar spine and femoral neck were achieved with TA treatment than with bisphosphonate treatment[1].

A fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. This fragment was also found to be an agonist at PTH1 and PTH2 receptors.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H227
• Precautionary statements: P210-P264-P270-P280-P301+P312-P330-P370+P378-P403+P235-P501
• WGK Germany: 3
• HS Code: 2937190000
• Hazardous Substances Data: 52232-67-4(Hazardous Substances Data)