Sodium4-Phenylbutyrate , ≥98% , 1716-12-7

Synonym(s):
Sodium phenylbutyrate;4-Phenylbutyric acid;4-PBA;Sodium 4-phenylbutyrate;TriButyrate

CAS NO.：1716-12-7

Empirical Formula: C10H11NaO2

Molecular Weight: 186.18

MDL number: MFCD00800247

EINECS: 605-612-7

PRODUCT Properties

• Melting point: 224-226°C (dec.)
• storage temp.: room temp
• solubility: H2O: ≥5mg/mL
• form: White to slightly yellow solid
• color: white to beige
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
• InChI: InChI=1S/C10H12O2.Na.H/c11-10(12)8-4-7-9-5-2-1-3-6-9;;/h1-3,5-6H,4,7-8H2,(H,11,12)
• InChIKey: OBKXEAXTFZPCHS-UHFFFAOYSA-N
• SMILES: C(C1C=CC=CC=1)CCC(=O)O.[NaH]
• CAS DataBase Reference: 1716-12-7(CAS DataBase Reference)

Description and Uses

Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
Sodium phenylbutyrate stimulates urinary nitrogen excretion. It is a prodrug, which undergoes β-oxidation to phenylacetate. Sodium phenylbutyrate is used to treat urea cycle disorder. It might be associated with menstrual dysfunction, amenorrhea and painful mucositis of the esophagus and stomach.
Sodium phenylbutyrate has been used as an endoplasmic reticulum (ER) stress inhibitor to study the role of ER stress in the expression of betatrophin.

Sodium 4-Phenylbutyrate is a histone-deacetylase inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H319
• Precautionary statements: P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• RTECS: CY9057220
• HS Code: 29163990