Home Categories Chemical Reagents tert-Butyldimethylsilyl chloride
A1467512

tert-Butyldimethylsilyl chloride , Used for GC derivatives , 18162-48-6

Synonym(s):
TBDMSCl;tert-Butyldimethylchlorosilane;tert-Butyldimethylsilyl chloride, tert-Butylchlorodimethylsilane, TBDMSCl;TBDMSCl solution;tert-Butyl(chloro)dimethylsilane

CAS NO.:18162-48-6

Empirical Formula: C6H15ClSi

Molecular Weight: 150.72

MDL number: MFCD00000501

EINECS: 242-042-4

Pack Size Price Stock Quantity
10G RMB663.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 86-89 °C (lit.)
Boiling point: 125 °C (lit.)
Density  0.87 g/mL at 20 °C(lit.)
vapor pressure  60-710Pa at 25℃
refractive index  n20/D 1.46
Flash point: 73 °F
storage temp.  Store below +30°C.
solubility  very sol nearly all common organic solvents such as THF, methylene chloride, and DMF.
form  white solid
color  white
Specific Gravity 1.225
Water Solubility  Soluble in chloroform and ethyl acetate. Insoluble in water.
Hydrolytic Sensitivity 7: reacts slowly with moisture/water
Sensitive  Moisture Sensitive
BRN  505999
Exposure limits ACGIH: TWA 20 ppm
OSHA: Ceiling 300 ppm; TWA 200 ppm
NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3)
InChIKey BCNZYOJHNLTNEZ-UHFFFAOYSA-N
LogP 2.5 at 20℃

Description and Uses

tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes. It acts as a versatile protecting reagent for amines, amides and alcohols.

Safety

Symbol(GHS) 
GHS02,GHS05,GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H225-H304-H314-H336-H361d-H373-H411
Precautionary statements  P210-P280-P301+P310+P331-P301+P330+P331-P303+P361+P353-P305+P351+P338+P310
Hazard Codes  C,F,T,Xn
Risk Statements  22-35-40-34-10-19-11-67-65-63-48/20-20/21/22-45-23/24/25-37-36/37/38
Safety Statements  26-36/37/39-46-62-45-25-16-28-27-33-29-53-36/37
RIDADR  UN 2925 4.1/PG 2
WGK Germany  2
RTECS  VV2000000
10-21
Hazard Note  Flammable/Corrosive/Moisture Sensitive
TSCA  Yes
HazardClass  4.1
PackingGroup  III
HS Code  29310095
Toxicity mouse,LDLo,intraperitoneal,1gm/kg (1000mg/kg),IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASED IMMUNE RESPONSE,Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975Vol. 27MAY1975,

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