A1467512
tert-Butyldimethylsilyl chloride , Used for GC derivatives , 18162-48-6
Synonym(s):
TBDMSCl;tert-Butyldimethylchlorosilane;tert-Butyldimethylsilyl chloride, tert-Butylchlorodimethylsilane, TBDMSCl;TBDMSCl solution;tert-Butyl(chloro)dimethylsilane
CAS NO.：18162-48-6
Empirical Formula: C6H15ClSi
Molecular Weight: 150.72
MDL number: MFCD00000501
EINECS: 242-042-4
| Pack Size | Price | Stock | Quantity |
| 10G | RMB663.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 86-89 °C (lit.) |
| Boiling point: | 125 °C (lit.) |
| Density | 0.87 g/mL at 20 °C(lit.) |
| vapor pressure | 60-710Pa at 25℃ |
| refractive index | n |
| Flash point: | 73 °F |
| storage temp. | Store below +30°C. |
| solubility | very sol nearly all common organic solvents such as
THF, methylene chloride, and DMF. |
| form | white solid |
| Specific Gravity | 1.225 |
| color | white |
| Water Solubility | Soluble in chloroform and ethyl acetate. Insoluble in water. |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 505999 |
| Exposure limits | ACGIH: TWA 20 ppm OSHA: Ceiling 300 ppm; TWA 200 ppm NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3) |
| InChIKey | BCNZYOJHNLTNEZ-UHFFFAOYSA-N |
| LogP | 2.5 at 20℃ |
| CAS DataBase Reference | 18162-48-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Silane, chloro(1,1-dimethylethyl)dimethyl-(18162-48-6) |
| EPA Substance Registry System | Silane, chloro(1,1-dimethylethyl)dimethyl- (18162-48-6) |
Description and Uses
tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes. It acts as a versatile protecting reagent for amines, amides and alcohols.
Safety
| Symbol(GHS) |      GHS02,GHS05,GHS07,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H225-H304-H314-H336-H361d-H373-H411 |
| Precautionary statements | P210-P280-P301+P310+P331-P301+P330+P331-P303+P361+P353-P305+P351+P338+P310 |
| Hazard Codes | C,F,T,Xn |
| Risk Statements | 22-35-40-34-10-19-11-67-65-63-48/20-20/21/22-45-23/24/25-37-36/37/38 |
| Safety Statements | 26-36/37/39-46-62-45-25-16-28-27-33-29-53-36/37 |
| RIDADR | UN 2925 4.1/PG 2 |
| WGK Germany | 2 |
| RTECS | VV2000000 |
| F | 10-21 |
| Hazard Note | Flammable/Corrosive/Moisture Sensitive |
| TSCA | Yes |
| HazardClass | 4.1 |
| PackingGroup | III |
| HS Code | 29310095 |
| Toxicity | mouse,LDLo,intraperitoneal,1gm/kg (1000mg/kg),IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASED IMMUNE RESPONSE,Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975Vol. 27MAY1975, |
