Trihexyphenidyl Hydrochloride , 98% , 52-49-3

Synonym(s):
(±)-α-Cyclohexyl-α-phenyl-1-piperidinepropanol hydrochloride;Trihexyphenidyl hydrochloride

CAS NO.：52-49-3

Empirical Formula: C20H31NO.ClH

Molecular Weight: 337.93

MDL number: MFCD00058212

EINECS: 200-142-5

PRODUCT Properties

• Melting point: Free base, mp 114.3-115.0°
• Density: 0.9801 (rough estimate)
• refractive index: 1.5790 (estimate)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: H₂O: soluble
• form: solid
• color: white
• Water Solubility: 670.9ug/L(22.5 ºC)
• Merck: 14,9695
• Stability: Stable at RT, Stable At Rt
• InChI: InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H
• InChIKey: QDWJJTJNXAKQKD-UHFFFAOYSA-N
• SMILES: C(O)(CCN1CCCCC1)(C1CCCCC1)C1C=CC=CC=1.Cl

Description and Uses

Trihexyphenidyl is an antagonist of M₁ muscarinic acetylcholine receptors. It binds to rat M₁ receptors in cerebral cortex selectively over rat M₂ receptors in heart tissue (IC₅₀s = 3.7 and 31 nM, respectively). Trihexyphenidyl inhibits contractions induced by acetylcholine in guinea pig ileum (IC₅₀ = 22 nM). It also inhibits oxotremorine-induced tremors and physostigmine-induced mortality in mice (ED₅₀s = 2 and 3.6 mg/kg, respectively). Trihexyphenidyl (20 mg/kg) improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD) that expresses mutant tyrosine hydroxylase (TH). Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson''s disease.

anticholinergic, antiparkinsonian

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 36
• RIDADR: 3249
• WGK Germany: 3
• RTECS: TN2625000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 2933399090
• Toxicity: TDLo orl-wmn: 800 mg/kg:BAH BJPYAJ 145,300,84