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A1451812

Boc-<I>N</I>-Me-Leu-OH , ≥99.0% , 53363-89-6

Synonym(s):
Boc-N-methyl-L-leucine;Boc-N-Me-Leu-OH;N-α-t.-Boc-N-α-methyl-L-leucine

CAS NO.:53363-89-6

Empirical Formula: C12H23NO4

Molecular Weight: 245.32

MDL number: MFCD00038522

Pack Size Price Stock Quantity
5G RMB2125.60 In Stock
25G RMB6047.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 55-60 °C
Boiling point: 338.2±21.0 °C(Predicted)
Density  1.053±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,2-8°C
pka 4.04±0.21(Predicted)
form  Solid
color  White to off-white
optical activity [α]20/D 36±2°, c = 1% in methylene chloride
BRN  2373250
InChI InChI=1S/C12H23NO4/c1-8(2)7-9(10(14)15)13(6)11(16)17-12(3,4)5/h8-9H,7H2,1-6H3,(H,14,15)/t9-/m0/s1
InChIKey YXJFAOXATCRIKU-VIFPVBQESA-N
SMILES C(O)(=O)[C@H](CC(C)C)N(C(OC(C)(C)C)=O)C
CAS DataBase Reference 53363-89-6(CAS DataBase Reference)

Description and Uses

Boc-N-methyl-L-leucine is the BOC (tert-butyloxycarbonyl) protected N-methylated leucine. The N-methylated amino acid is quite useful in the peptide synthesis, giving a lot of improved properties to peptide. Studies have shown that peptide containing N-methylated amino acids obtain increased proteolytic stability, increased membrane permeability, and altered conformation. The effects of N-methylated amino acids are quite important in the development of therapeutic peptide compound as well as in the assay of biological activity of some modified peptides. BOC group can be easily removed by treatment with strong acids such as trifluoroacetic acid.

Boc-N-methyl-L-leucine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3
HS Code  2924 19 00
HazardClass  IRRITANT

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