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A1416112

Bimatoprost , ≥99% , 155206-00-1

Synonym(s):
Bimatoprost

CAS NO.:155206-00-1

Empirical Formula: C25H37NO4

Molecular Weight: 415.57

MDL number: MFCD03411999

EINECS: 642-890-9

Pack Size Price Stock Quantity
10MG RMB119.20 In Stock
50MG RMB476.80 In Stock
100MG RMB788.00 In Stock
500MG RMB2228.80 In Stock
1g RMB3510.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 66-68°C
Boiling point: 629.8±55.0 °C(Predicted)
Density  1.145±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
form  solid
pka 14.25±0.20(Predicted)
color  White to Off-White
BCS Class 3
Stability: Light Sensitive
InChIKey AQOKCDNYWBIDND-FTOWTWDKSA-N
SMILES C(NCC)(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCC1=CC=CC=C1

Description and Uses

Bimatoprost was first introduced in the US and Brazil as Lumigan?, an ophthalmic solution (0.03%) for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, a proven risk of glaucomatous visual field loss. Bitamoprost is a new agent belonging to the PGF analog class of prostamides launched in this indication after latanoprost, the most efficaceous topical medication currently available. This synthetic fatty acid amide can be prepared by esterification of 17- phenyl-18,19,20-trinorprostaglandin F followed by ethylamidation. Bimatoprost, as related prostamides, is devoid of typical activities associated with PGF2,, analogs; it exhibits a unique pharmacological profile in contracting the feline iris sphincter with an EC50 of 34 nM without interacting with any known prostanoid receptors. Thus it mimics the action of endogenous prostamides on specific receptors that lower IOP by increasing aqueous humor outflow through both pressure-insensitive and pressure-sensitive pathways without reducing humor formation. In a 3-month controlled clinical trial of efficacy and safety in patients with elevated IOP, bimatoprost demonstrated lower mean intraocular pressures at every time point throughout the study, as well as a good tolerance and systemic safety profile compared to latanoprost.

Antiglaucoma. Synthetic prostamide; structurally related to prostaglandin F2a.

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H360F
Precautionary statements  P201-P301+P312+P330-P308+P313
WGK Germany  3

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