A1414312
Bezafibrate , ≥98% , 41859-67-0
Synonym(s):
2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid
CAS NO.：41859-67-0
Empirical Formula: C19H20ClNO4
Molecular Weight: 361.82
MDL number: MFCD00078970
EINECS: 255-567-9
| Pack Size | Price | Stock | Quantity |
| 1G | RMB69.60 | In Stock |
|
| 5G | RMB126.40 | In Stock |
|
| 25G | RMB448.00 | In Stock |
|
| 100G | RMB1414.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 184 °C |
| Boiling point: | 572.1±45.0 °C(Predicted) |
| Density | 1.260±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: soluble |
| form | solid |
| pka | 3.29±0.10(Predicted) |
| color | White to Off-White |
| Merck | 14,1195 |
| Stability: | Hygroscopic |
| LogP | 2.504 (est) |
Description and Uses
Bezafibrate is a non-selective agonist of peroxisome proliferator-activated receptors (PPARs; EC50s = 50, 60, and 20 μM for human PPARα, PPARγ, and PPARδ, respectively). It reduces triglyceride levels and the size of lipid droplets in an oleic acid-induced HepaRG hepatocyte model of steatosis when used at a concentration of 25 μM. Bezafibrate (10 mg/kg per day) reduces plasma VLDL and LDL mass and triglyceride and free fatty acid levels in a high-fructose plus lard diet-induced rat model of insulin resistance.
anti-hyperlipoproteinemic
