Amfebutamone (Bupropion) HCl , ≥98%(HPLC) , 31677-93-7

CAS NO.：31677-93-7

Empirical Formula: C13H18ClNO.HCl

Molecular Weight:

MDL number: MFCD00055209

EINECS: 250-759-9

PRODUCT Properties

• Melting point: 233-234°
• Flash point: 9°C
• storage temp.: 2-8°C
• solubility: Soluble in DMSO (40 mg/ml)
• pka: 7.9(at 25℃)
• form: solid
• color: white
• Water Solubility: Soluble in water (>25 mg/ml), ethanol 193mg/ml, 0.1 N HCl 333 mg/ml
• Merck: 14,1499
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• LogP: 3.468 (est)

Description and Uses

Bupropion HCl (31677-94-7) is a clinically useful antidepressant that inhibits monoamine transporters DAT, NET, and SERT (Kis for dopamine uptake = 2.8, 1.4, 45 μM).1 Also acts as a noncompetitive antagonist at nicotinic acetylcholine receptors (AChRs).2 At higher concentrations (50 μM), stimulates pro-inflammatory cytokines and TLR2/TLR4 and JAK2/STAT3 in human peripheral blood mononuclear cells (PBMCs).3

Antidepressant.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: UG8858000
• HS Code: 2923900100
• Toxicity: LD50 in mice, rats (mg/kg): 230, 210 i.p.; 575, 600 orally (Soroko)