Busulfan , 98% , 55-98-1

Synonym(s):
1,4-Butanediol dimethanesulfonate;Busulfan

CAS NO.：55-98-1

Empirical Formula: C6H14O6S2

Molecular Weight: 246.3

MDL number: MFCD00007562

EINECS: 200-250-2

PRODUCT Properties

• Melting point: 114-117 °C(lit.)
• Boiling point: 359.3°C (rough estimate)
• Density: 1.305 (estimate)
• refractive index: 1.5630 (estimate)
• Flash point: 9℃
• storage temp.: Inert atmosphere,Room Temperature
• solubility: Very slightly soluble in water, freely soluble in acetone and in acetonitrile, very slightly soluble in ethanol (96 per cent).
• form: Crystalline Powder
• color: Pale Brown
• Water Solubility: Decomposes
• Merck: 14,1505
• BRN: 1791786
• Stability: Moisture Sensitive

Description and Uses

Chemically, busulfan is classified as an alkyl sulfonate. One or both of the methylsulfonate ester moieties can be displaced by the nucleophilic N7 of guanine, leading to monoalkylated and cross-linked DNA. The extent of alkyl sulfonate–mediated DNA interstrand cross-linking has been shown to vary with the length of the alkyl chain between sulfonate esters, with the tetramethylene-containing busulfan showing less interstrand cross-linking capability than hexamethylene, methylene, or octamethylene analogues. Intrastrand cross-linking also occurs, preferentially at 5′-GA-3′ but also at 5′-GG-3′ sequences. Alkylation of Cys sulfhydryl groups is yet another mechanism of cytotoxicity.

Alkylating agent with antileukemic activity. Antineoplastic

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301-H340-H350-H360FD
• Precautionary statements: P202-P264-P270-P280-P301+P310-P405
• Hazard Codes: T+,T,F
• Risk Statements: 45-26/27/28-63-46-36/37/38-23/24/25-39/23/24/25-11
• Safety Statements: 53-36/37/39-45-28A-36/37-16-7
• RIDADR: UN 2811 6.1/PG 1
• WGK Germany: 3
• RTECS: EK1750000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29053990
• Toxicity: LD50 i.v. in rats: 1.8 mg/kg (Scherf)