Bestatin hydrochloride , ≥98%(HPLC) , 65391-42-6

Synonym(s):
N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine hydrochloride

CAS NO.：65391-42-6

Empirical Formula: C16H25ClN2O4

Molecular Weight: 344.83

MDL number: MFCD00058004

PRODUCT Properties

• Melting point: 216-218 °C
• storage temp.: 2-8°C
• solubility: H₂O: 25 mg/mL, clear, colorless
• form: White to off-white powder.
• color: White
• Water Solubility: Soluble in water (4 mg/ml, warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.
• BRN: 4628066
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20° for up to 1 month.
• InChIKey: XGDFITZJGKUSDK-UDYGKFQRSA-N
• CAS DataBase Reference: 65391-42-6(CAS DataBase Reference)

Description and Uses

Bestatin HCl (65391-42-6) inhibits leucine aminopeptidase and aminopeptidases B and N. Inhibits leukotriene A4 hydrolase. Displays immunostimulant activity via activation of macrophages and T lymphocytes. Displays antitumor activity.

Bestatin is an inhibitor of amino peptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the amino peptidase activity of LTA4 hydrolase with a Ki value of 201 nM. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation. It does not inhibit carboxypeptidases.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P280-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• F: 3-10
• HS Code: 29242995