Methazolamide , 98% , 554-57-4
Synonym(s):
N-(4-Methyl-2-sulfamoyl-Δ2-1,3,4-thiadiazolin-5-ylidene) acetamide;5-Acetylimino-4-methyl-·2-1,3,4-thiadiazoline-2-sulfonamide;Methazolamide;N-[5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide;N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide, Carbonic Anhydrase Inhibitor, Methazolamide, CAIX Inhibitor III
CAS NO.：554-57-4
Empirical Formula: C5H8N4O3S2
Molecular Weight: 236.27
MDL number: MFCD00083416
EINECS: 209-066-7
| Pack Size | Price | Stock | Quantity |
| 250mg | RMB175.20 | In Stock |
|
| 1g | RMB263.20 | In Stock |
|
| 5g | RMB952.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 208 °C (dec.) (lit.) |
| Boiling point: | 402.0±28.0 °C(Predicted) |
| Density | 1.6625 (rough estimate) |
| refractive index | 1.6270 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| pka | 7.30(at 25℃) |
| form | White powder |
| color | white to beige |
| Water Solubility | 2.835g/L(25 ºC) |
| InChIKey | FLOSMHQXBMRNHR-QPJJXVBHSA-N |
| CAS DataBase Reference | 554-57-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Methazolamide(554-57-4) |
| EPA Substance Registry System | Acetamide, N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]- (554-57-4) |
Description and Uses
Methazolamide is a carbonic anhydrase inhibitor (IC50 = 130 nM). It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and reduces cerebral edema in a mouse model of SAH. Methazolamide is larvicidal, with a larvicidal concentration (LC50) value of 724 ppm, but has no activity when administered in the diet to adult A. aegypti. Formulations containing methazolamide have been used for the treatment of glaucoma.
Action of this drug is similar to that of acetazolamide, and it is used for lowering intraocular pressure in treating wide-angle and secondary glaucoma, and before surgical intervention for severe wide-angle glaucoma.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H351 |
| Precautionary statements | P201-P280-P301+P312-P302+P352+P312-P304+P340+P312-P308+P313 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-40 |
| Safety Statements | 22-36 |
| WGK Germany | 3 |
| RTECS | AC6350000 |
| HS Code | 2935904000 |
| Hazardous Substances Data | 554-57-4(Hazardous Substances Data) |
