A1285712
Bromo-tris-pyrrolidinophosphonium hexafluorophosphate , 98% , 132705-51-2
Synonym(s):
Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate;PyBroP
CAS NO.：132705-51-2
Empirical Formula: C12H24BrF6N3P2
Molecular Weight: 466.19
MDL number: MFCD00077412
EINECS: 620-834-4
| Pack Size | Price | Stock | Quantity |
| 1G | RMB36.80 | In Stock |
|
| 5G | RMB79.20 | In Stock |
|
| 25G | RMB287.20 | In Stock |
|
| 100g | RMB1119.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 100 °C |
| storage temp. | -20°C |
| solubility | DMF: 0.4 g/mL, clear |
| form | Powder |
| color | White to off-white |
| Water Solubility | moderately soluble |
| Sensitive | Moisture Sensitive |
| BRN | 7845702 |
| Stability: | Moisture Sensitive |
| InChIKey | CYKRMWNZYOIJCH-UHFFFAOYSA-N |
Description and Uses
It can be used as a coupling reagent:
- For Suzuki–Miyaura cross-coupling of phenols and arylboronic acids to synthesize biaryls and heterobiaryls.
- To functionalize pyrimidines (synthesized from 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via the Kappe dehydrogenation) by using various nucleophiles.
- To synthesize formamidines by coupling with various primary amines and N,N-diisopropylethylamine.
It can also be used as an activating reagent:
- For the activation of C-OH bond in tautomerizable heterocycles to form the phosphonium salt which aids the Sonogashira coupling of heterocycles with various alkynes.
- For the one–pot activation of C-O bond in phenols and further coupling reaction with phosphine oxide or phosphite to form C-P bonds.
Safety
| Symbol(GHS) |  GHS05 |
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 |
| Hazard Codes | Xi,C |
| Risk Statements | 36/37/38-34 |
| Safety Statements | 26-36-45-36/37/39-27 |
| WGK Germany | 3 |
| F | 10-21 |
| HS Code | 2933 99 80 |
