Puromycindihydrochloride , Super pure , 58-58-2
Synonym(s):
(2 S)-2-Amino-N-((2 S,3 S,4 R,5 R)-5-(6-(dimethylamino)purin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl)-3-(4-methoxyphenyl);3′-[α-Amino-p-methoxyhydrocinnamamido]-3′-deoxy-N,N-dimethyladenosine dihydrochloride;Puromycin, Dihydrochloride, Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 58-58-2 - Calbiochem
CAS NO.：58-58-2
Empirical Formula: C22H31Cl2N7O5
Molecular Weight: 544.43
MDL number: MFCD00012691
EINECS: 200-387-8
| Pack Size | Price | Stock | Quantity |
| 25mg | RMB271.20 | In Stock |
|
| 100mg | RMB1039.20 | In Stock |
|
| 500mg | RMB4159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 168-170℃ |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O: soluble50mg/mL (Sterilize stock solution by filtration using 0.22 μm filter then store in aliquots at 20 °C.) |
| form | solution |
| color | yellow-white |
| Water Solubility | Soluble in water |
| Merck | 14,7943 |
| BRN | 3853613 |
| Stability: | Stable. Heat sensitive. Incompatible with strong oxidizing agents. |
| InChIKey | MKSVFGKWZLUTTO-NGOAXYITSA-N |
| EPA Substance Registry System | Adenosine, 3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-, dihydrochloride (58-58-2) |
Description and Uses
Puromycin (58-58-2) is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is a protein synthesis inhibitor that disrupts peptide transfer on ribosomes causing premature chain termination.1 It is an inhibitor of dipeptidyl-peptidase II and cytosolic alanyl aminopeptidase.2 Puromycin also inhibits protein transport in mitochondria.3
Puromycin dihydrochloride is the salt of puromycin, a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypansomal agent with antibiotic activity. While the salt shares the same pharmacological properties as puromycin free base, its greater water solubility offers advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems, the free base and salt may behave differently.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn |
| Risk Statements | 22-40 |
| Safety Statements | 24/25 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | AU7355000 |
| F | 3-8-10 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29419090 |
| Toxicity | LD50 oral in guinea pig: 600mg/kg |
