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A1270250

Puromycindihydrochloride , Super pure , 58-58-2

Synonym(s):
(2 S)-2-Amino-N-((2 S,3 S,4 R,5 R)-5-(6-(dimethylamino)purin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl)-3-(4-methoxyphenyl);3′-[α-Amino-p-methoxyhydrocinnamamido]-3′-deoxy-N,N-dimethyladenosine dihydrochloride;Puromycin, Dihydrochloride, Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 58-58-2 - Calbiochem

CAS NO.:58-58-2

Empirical Formula: C22H31Cl2N7O5

Molecular Weight: 544.43

MDL number: MFCD00012691

EINECS: 200-387-8

Pack Size Price Stock Quantity
25mg RMB271.20 In Stock
100mg RMB1039.20 In Stock
500mg RMB4159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 168-170℃
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  H2O: soluble50mg/mL (Sterilize stock solution by filtration using 0.22 μm filter then store in aliquots at 20 °C.)
form  solution
color  yellow-white
Water Solubility  Soluble in water
Merck  14,7943
BRN  3853613
Stability: Stable. Heat sensitive. Incompatible with strong oxidizing agents.
InChIKey MKSVFGKWZLUTTO-NGOAXYITSA-N

Description and Uses

Puromycin (58-58-2) is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is a protein synthesis inhibitor that disrupts peptide transfer on ribosomes causing premature chain termination.1 It is an inhibitor of dipeptidyl-peptidase II and cytosolic alanyl aminopeptidase.2 Puromycin also inhibits protein transport in mitochondria.3

Puromycin dihydrochloride is the salt of puromycin, a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypansomal agent with antibiotic activity. While the salt shares the same pharmacological properties as puromycin free base, its greater water solubility offers advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems, the free base and salt may behave differently.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22-40
Safety Statements  24/25
RIDADR  3249
WGK Germany  3
RTECS  AU7355000
3-8-10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29419090
Toxicity LD50 oral in guinea pig: 600mg/kg

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