Borane tetrahydrofuran complex solution , 1.0MINTHF, containing 5mmol boro -sodium stabilizer , 14044-65-6

CAS NO.：14044-65-6

Empirical Formula: C4H11BO

Molecular Weight: 85.94

MDL number: MFCD00012429

EINECS: 237-881-8

PRODUCT Properties

• Melting point: -17 °C
• Boiling point: 35 °C
• Density: 0.898 g/mL at 25 °C
• Flash point: 1 °F
• storage temp.: Store at <= 20°C.
• form: Liquid
• color: Colorless
• Water Solubility: REACTS
• Sensitive: Air & Moisture Sensitive
• BRN: 3668402
• Exposure limits: ACGIH: TWA 50 ppm; STEL 100 ppm (Skin); OSHA: TWA 200 ppm(590 mg/m3); NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3)
• Stability: Stable, but may form explosive peroxides in contact with air. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents, alcohols. Reacts violently with water. Highly flammable. Store under inert gas.
• CAS DataBase Reference: 14044-65-6(CAS DataBase Reference)
• EPA Substance Registry System: Boron, trihydro(tetrahydrofuran)-, (T-4)- (14044-65-6)

Description and Uses

Borane tetrahydrofuran complex (BH3-THF) is widely used as a reducing agent in organic synthesis. It is also used as a reagent in hydroboration reactions.It is a charge-transfer complex that is a useful surrogate for diborane1 in organic synthesis. It can be used to reduce carboxylic acids to alcohols or nitriles to primary amines. It reacts with olefins to add the BH2 functional group. Alkyl- or arylboranes formed in this way can further react with unsaturated compounds such as olefins, imines, ketones, and alkynes (the hydroboration reaction) to make useful boron-containing intermediates.

Borane-tetrahydrofuran complex is used to reduce Nylon surface amide groups to secondary amines.It is an important reagent used in the reduction of certain functional groups viz. aldehyde, ketone, carboxylic acid, amide, oxime, imine and nitrile. It is also used as hydro borating agent. It acts as a borane source for oxazaborolidine catalyzed asymmetric reductions.

Safety

• Symbol(GHS): GHS02,GHS05,GHS07,GHS08
• Signal word: Danger
• Hazard statements: H225-H260-H302-H315-H318-H335-H351-H319-H333
• Precautionary statements: P223-P303+P361+P353-P305+P351+P338-P405-P501a-P210-P231+P232-P280-P370+P378-P402+P404-P403+P235
• Hazard Codes: F,Xn,Xi
• Risk Statements: 14/15-19-22-36/37/38-41-37/38-11-67-66-40-36/37
• Safety Statements: 16-33-36/37/39-7/9-7/8-43-37/39-26-36-29-36/37
• RIDADR: UN 3399 4.3/PG 1
• WGK Germany: 3
• F: 1-10-13-34
• TSCA: Yes
• HazardClass: 4.3
• PackingGroup: I
• HS Code: 29321900