Bleomycin sulfate from Streptomyces verticillus , 1.5-2.0units/mg , 9041-93-4
Synonym(s):
Blenoxane;Bleo;Bleomycin Sulfate, Streptomyces verticillus - CAS 9041-93-4 - Calbiochem;Blexane
CAS NO.：9041-93-4
Empirical Formula: C110H168N34O46S7
Molecular Weight: 2927.17
MDL number: MFCD00070310
EINECS: 232-925-2
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB223.20 | In Stock |
|
| 25MG | RMB501.60 | In Stock |
|
| 100MG | RMB1997.60 | In Stock |
|
| 500mg | RMB7039.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 200-204°C (dec.) |
| storage temp. | 2-8°C |
| solubility | H2O: 20 mg/mL |
| form | powder |
| color | white |
| Water Solubility | Soluble in water or DMSO |
| Merck | 14,1318 |
| Stability: | Stable for 1 year from the date of purchase. Solutions in distilled water may be stored at -20°C for up to 3 months. |
| InChIKey | OOXTWFJZZAJGKA-YWZNXBAZNA-N |
| CAS DataBase Reference | 9041-93-4(CAS DataBase Reference) |
Description and Uses
Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1?and RNA2. Induces double-strand DNA damage.3?Commonly used to induce lung fibrosis in animal disease models.4,5?Anticancer agent in clinical use.6
Bleomycin sulfate binds to DNA, and can inhibit DNA synthesis and causes scission of DNA. Cleaves DNA, requires binding to oxygen and a metal ion, such as copper or iron. Able to cleave RNA, but at less and more selective degree. Also reported to induce and regulate apoptosis in a variety of cells, and inhibit tumor angiogenesis.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Danger |
| Hazard statements | H340-H351-H361fd |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
| Hazard Codes | T,Xi |
| Risk Statements | 46-40-36/37/38-63 |
| Safety Statements | 53-36/37-45-36-26 |
| WGK Germany | 3 |
| RTECS | EC5991990 |
| F | 10 |
| HS Code | 2941906000 |
