Berberine Chloride Hydrate , 98% , 141433-60-5

Synonym(s):
Berberine;Berberine chloride form;Natural Yellow 18

CAS NO.：141433-60-5

Empirical Formula: C20H18ClNO4

Molecular Weight: 371.81

MDL number: MFCD00011939

EINECS: 211-195-9

PRODUCT Properties

• Melting point: 204-206 °C (dec.)
• storage temp.: Sealed in dry,Room Temperature
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• Colour Index: 75160
• color: Pale Yellow to Yellow
• Water Solubility: Soluble in water.
• Sensitive: Light Sensitive
• Merck: 14,1154
• BRN: 3836585
• Stability: Hygroscopic
• InChIKey: VKJGBAJNNALVAV-UHFFFAOYSA-M
• CAS DataBase Reference: 141433-60-5(CAS DataBase Reference)

Description and Uses

Berberine chloride occurs together with Neprotine (q.v.) in Berberis insignis Hook, B. umbellata Wall and Mahonia nepalensis DC. (Syn. Berberis nepalensis Spreng.). It is optically inactive and crystallizes from H2O with 5.5 H2O. It yields crystal_x0002_line salts, e.g. the nitrate, m.p. 265-7°C (dec.); sulphate, m.p. 271-3°C (dec.) and the picrate, m.p. 231°C (dec.). The base also furnishes a methyl ether, m.p. 265°C and on catalytic hydrogenation gives the tetrahydro derivative, m.p. 213-5°C (dec.). The ultraviolet spectrum resembles that of berberine (q.v.). Oxidation with KMn04 in Me2CO gives hemipinic acid, identified as the ethylimide, m.p. 90°C.

Berberine chloride is mainly used to treat gastroenteritis, dysentery and other intestinal infections, conjunctivitis and suppurative otitis media.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 20/21/22
• WGK Germany: 2
• RTECS: DR9866400
• F: 3-10
• TSCA: Yes
• HS Code: 29399990