Heparinsodium , 9041-08-1
Synonym(s):
HEP, Na;Heparin sodium;Heparin sodium salt;Heparin, Sodium Salt, Porcine Intestinal Mucosa - CAS 2608411 - Calbiochem
CAS NO.：9041-08-1
Empirical Formula: (C12H16NS2Na3)20
Molecular Weight:
MDL number: MFCD00081689
EINECS: 232-681-7
| Pack Size | Price | Stock | Quantity |
| 250mg | RMB239.20 | In Stock |
|
| 1g | RMB639.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >181°C (dec.) |
| alpha | D25 +47° (c = 1.5 in water) |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL, clear, faintly yellow |
| form | crystalline (fine) |
| color | white |
| PH | pH (10g/l, 25℃) : 6.0～8.0 |
| Water Solubility | Soluble in water, dimethyl sulfoxide and ethanol. |
| Merck | 14,4653 |
| Stability: | Stable. Incompatible with strong oxidizing agents, strong bases. |
| CAS DataBase Reference | 9041-08-1 |
| EPA Substance Registry System | Heparin, sodium salt (9041-08-1) |
Description and Uses
Reviparin sodium, a second-generation low molecular weight heparin produced from porcine mucosal heparin, has been introduced for the prevention of deep vein thrombosis and pulmonary embolism following surgery. It has sustained activity and increased bioavailability over unfractioned heparin. More noticeably, reviparin shows a pronounced inhibitory effect, both in vitro and in vivo , on smooth muscle cell proliferation which plays a predominant role in restenosis following angioplasty. Indeed, a lower incidence of restenosis without major bleeding complications has been reported for reviparin treated patients who successfully underwent percutaneous transluminal coronary angioplasty.
Heparin sodium salt is used as a blood anti-coagulant. It is also used as an effective inhibitor of mesenchymal cell proliferation. Further, it binds to antithrombin III, which inhibits coagulation proteases. It is used as a major component of serum free media for preventing cell aggregation. It is also used as an anti-cancer agent in in vitro cancer research.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Risk Statements | 36/37/38-42/43 |
| Safety Statements | 22-24-26-36/37 |
| WGK Germany | 2 |
| RTECS | MI0850000 |
| F | 3-10 |
| TSCA | Yes |
| HS Code | 30019010 |
| Toxicity | LD50 oral in rat: > 779000iu/kg |