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A1204750

Heparinsodium , 9041-08-1

Synonym(s):
HEP, Na;Heparin sodium;Heparin sodium salt;Heparin, Sodium Salt, Porcine Intestinal Mucosa - CAS 2608411 - Calbiochem

CAS NO.:9041-08-1

Empirical Formula: (C12H16NS2Na3)20

Molecular Weight:

MDL number: MFCD00081689

EINECS: 232-681-7

Pack Size Price Stock Quantity
250mg RMB239.20 In Stock
1g RMB639.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >181°C (dec.)
alpha  D25 +47° (c = 1.5 in water)
storage temp.  2-8°C
solubility  H2O: 50 mg/mL, clear, faintly yellow
form  crystalline (fine)
color  white
PH pH (10g/l, 25℃) : 6.0~8.0
Water Solubility  Soluble in water, dimethyl sulfoxide and ethanol.
Merck  14,4653
Stability: Stable. Incompatible with strong oxidizing agents, strong bases.

Description and Uses

Reviparin sodium, a second-generation low molecular weight heparin produced from porcine mucosal heparin, has been introduced for the prevention of deep vein thrombosis and pulmonary embolism following surgery. It has sustained activity and increased bioavailability over unfractioned heparin. More noticeably, reviparin shows a pronounced inhibitory effect, both in vitro and in vivo , on smooth muscle cell proliferation which plays a predominant role in restenosis following angioplasty. Indeed, a lower incidence of restenosis without major bleeding complications has been reported for reviparin treated patients who successfully underwent percutaneous transluminal coronary angioplasty.

Heparin sodium salt is used as a blood anti-coagulant. It is also used as an effective inhibitor of mesenchymal cell proliferation. Further, it binds to antithrombin III, which inhibits coagulation proteases. It is used as a major component of serum free media for preventing cell aggregation. It is also used as an anti-cancer agent in in vitro cancer research.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
Risk Statements  36/37/38-42/43
Safety Statements  22-24-26-36/37
WGK Germany  2
RTECS  MI0850000
3-10
TSCA  Yes
HS Code  30019010
Toxicity LD50 oral in rat: > 779000iu/kg

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