Benzamidine hydrochloride , 98% , 1670-14-0

Synonym(s):
Additive Screening Solution 37/Kit-No 78374;Benzamidine hydrochloride solution;Benzamidine, Hydrochloride - CAS 1670-14-0 - Calbiochem

CAS NO.：1670-14-0

Empirical Formula: C7H9ClN2

Molecular Weight: 156.61

MDL number: MFCD00013025

EINECS: 216-795-4

PRODUCT Properties

• Melting point: 86-88 °C(lit.)
• storage temp.: 2-8°C
• solubility: DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 3 mg/ml
• form: Powder
• color: White to off-white
• PH: 4.0 to 6.5(50g/L, 25 ℃)
• Water Solubility: soluble
• BRN: 3594959
• Stability: Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily
• InChIKey: LZCZIHQBSCVGRD-UHFFFAOYSA-N

Description and Uses

Benzamidine hydrochloride is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.
In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.

Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 μM, respectively). In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• RTECS: CV6260000
• F: 3-21
• HS Code: 29252900