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A1183450

Lobelinehydrochloride , >99% , 134-63-4

Synonym(s):
α-Lobeline hydrochloride;(−)-Lobeline hydrochloride;L-Lobeline hydrochloride

CAS NO.:134-63-4

Empirical Formula: C22H28ClNO2

Molecular Weight: 373.92

MDL number: MFCD00082455

EINECS: 205-150-2

Pack Size Price Stock Quantity
100mg RMB761.60 In Stock
250mg RMB1599.20 In Stock
1g RMB4479.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 183-185 °C (dec.)(lit.)
alpha  D20 -43° (c = 2)
refractive index  -57.5 ° (C=1, H2O)
storage temp.  Inert atmosphere,Room Temperature
solubility  H2O: 25 mg/mL
form  powder
color  white to off-white
optical activity [α]20/D 56.8°, c = 2 in H2O
Merck  14,5551
BRN  3920196
LogP 3.610 (est)

Description and Uses

(–)-Lobeline is an alkaloid that has been found in Lobelia and has diverse biological activities. It binds to nicotinic acetylcholine receptors (nAChRs) in rat brain homogenates (Ki = 4 nM) and has antinociceptive effects in the tail-flick assay in mice. (–)-Lobeline (0.3 and 0.9 mg/kg) reduces the number of errors in a repeated acquisition procedure in the radial arm maze in rats. It also decreases immobility time in the forced swim test and feeding latency in the novelty suppressed feeding test, indicating antidepressant-like activity, in mice when administered at doses of 1 and 4 mg/kg.

A neuronal nicotinic acetylcholine receptor agonist. A CNS stimulant.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301+H331
Precautionary statements  P301+P310+P330-P304+P340+P311
Hazard Codes  T
Risk Statements  23/25
Safety Statements  36/37/39-45
RIDADR  UN 1544 6.1/PG 3
WGK Germany  3
RTECS  OJ8490100
8
HazardClass  6.1(b)
PackingGroup  III

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