Imetitdihydrobromide , 95% , 32385-58-3

CAS NO.：32385-58-3

Empirical Formula: C6H12Br2N4S

Molecular Weight: 332.06

MDL number: MFCD00153816

PRODUCT Properties

• storage temp.: Store at RT
• solubility: H₂O: soluble
• form: solid
• color: off-white
• Water Solubility: Freely soluble in water, practically insoluble in acetone /n

Description and Uses

Imetit is a histamine H₃ and H₄ receptor agonist (K_is = 0.3 and 2.7 nM, respectively, in radioligand binding assays). It is selective for histamine H₃ and H₄ receptors over H₁ and H₂ receptors at concentrations up to 100 μM, as well as the serotonin (5-HT) receptor subtype 5-HT₃ (K_i = 240 nM)., Imetit reduces potassium-induced increases in histamine levels in isolated rat cerebral cortex slices (EC₅₀ = 2.8 nM). It increases scratching in mice (ED₅₀ = 0.9 μmol), an effect that is reduced by the H₃ receptor antagonist thioperamide .

Imetit dihydrobromide is a high affinity agonist at the histamine H3- and H4-receptors.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3