Acetazolamide , 99% , 59-66-5

Synonym(s):
5-Acetamido-1,3,4-thiadiazole-2-sulfonamide;Acetazolamide;N-(5-[Aminosulfonyl]-1,3,4-thiadiazol-2-yl)acetamide;N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide

CAS NO.：59-66-5

Empirical Formula: C4H6N4O3S2

Molecular Weight: 222.25

MDL number: MFCD00003105

EINECS: 200-440-5

PRODUCT Properties

• Melting point: 258-259 °C
• Density: 1.610 (estimate)
• refractive index: 1.6270 (estimate)
• storage temp.: 2-8°C
• solubility: Soluble in NH4OH (50 mg/mL), DMSO, Methanol and slightly soluble in Ethanol.
• pka: 7.2(at 25℃)
• form: solid
• color: White to Off-White
• Water Solubility: <0.1 g/100 mL at 22 ºC
• λmax: 265nm(H2O)(lit.)
• Merck: 14,53
• BRN: 212994
• BCS Class: 4
• Stability: Hygroscopic
• InChIKey: BZKPWHYZMXOIDC-UHFFFAOYSA-N
• CAS DataBase Reference: 59-66-5(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetylamino-1,3,4-thiadiazole-5-sulfonamide(59-66-5)
• EPA Substance Registry System: Acetazolamide (59-66-5)

Description and Uses

Acetazolamide is a weak diuretic with limited use in edema associated with cardiac insufficiency, glaucoma, minor epileptic attacks, and altitude sickness.

Acetazolamide is used for epilepsy in the absence of attacks and also in conjunction with other antiepileptic drugs.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
• Hazard Codes: Xi
• Risk Statements: 36/38-36/37/38
• Safety Statements: 26-36
• RIDADR: 2811
• WGK Germany: 2
• RTECS: AC8225000
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29350090
• Hazardous Substances Data: 59-66-5(Hazardous Substances Data)
• Toxicity: LD50 oral in mouse: 4300mg/kg