Zuclopenthixol , 98% , 53772-83-1

CAS NO.：53772-83-1

Empirical Formula: C22H25ClN2OS

Molecular Weight: 400.96

MDL number:

EINECS: 258-758-5

PRODUCT Properties

• Melting point: 56-60°C
• Boiling point: 577.4±50.0 °C(Predicted)
• Density: 1.289±0.06 g/cm3(Predicted)
• storage temp.: -20°C Freezer, Under Inert Atmosphere
• solubility: Chloroform (Slightly), Methanol (Slightly)
• form: Solid
• pka: 14.96±0.10(Predicted)
• color: White to Off-White

Description and Uses

Zuclopenthixol is a dopamine receptor antagonist (K_is = 9.8 and 1.5 nM for D₁ and D₂ receptors, respectively). It also binds to serotonin (5-HT) receptor subtypes 5-HT₂ and 5-HT₆, α₁-adrenergic, and histamine receptors (K_is = 7.6, 3, 33, and 169 nM, respectively) but not α₂-adrenergic receptors (K_i = >4,300 nM). Zuclopenthixol inhibits dopamine-induced accumulation of cAMP in rat striatal homogenates (IC₅₀ = 330 nM; K_i = 16 nM). It decreases stereotypic behavior induced by methylphenidate in mice (ED₅₀ = 0.8 μmol/kg) and by apomorphine in rats and dogs (ED₅₀s = 6.0 and 1.3 μmol/kg, respectively). Zuclopenthixol (0.7 and 1.4 mg/kg, i.p.) administered prior to testing enhances memory retrieval in rats in an inhibitory avoidance task without affecting locomotor activity.

Zuclopenthixol is an anti-psychotic drug. It is an inhibitor of coxsackievirus B3. Also, it is an intermediate used in the synthesis of Zuclopenthixol Decanoate (Z701490), which is used in the maintenance treatment of chronic schizophrenic patients. It is one of the three distinct formulations of Zuclopenthixol namely, zuclopenthixol dihydrochloride, zuclopenthixol acetate or Acuphase and zuclopenthixol decanoate.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P330-P501