PTC209 , ≥98%(HPLC) , 315704-66-6
Synonym(s):
BMI-1 Expression Inhibitor, PTC-209 - CAS 315704-66-6 - Calbiochem;FLVI2/BMI1 Expression Inhibitor, MGC12685 Expression Inhibitor, PCGF4 Expression Inhibitor, PTC209; RNF51 Expression Inhibitor;N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine
CAS NO.：315704-66-6
Empirical Formula: C17H13Br2N5OS
Molecular Weight: 495.19
MDL number: MFCD02110649
EINECS: 808-910-7
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB719.20 | In Stock |
|
| 10mg | RMB1199.20 | In Stock |
|
| 25mg | RMB2399.20 | In Stock |
|
| 50mg | RMB3759.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Density | 1.86±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| pka | 3.77±0.30(Predicted) |
| form | powder |
| color | white to brown |
| Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 315704-66-6 |
Description and Uses
PTC-209 (315704-66-6) is an inhibitor of BMI-1 (IC50 = 500 nM), part of the polycomb repressive complex 1 (PCR1).1? It inhibited endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells resulting in reduced tumor volume as well as reduced cancer initiating cell (CIC) number.?? PTC-209 displayed potent in vivo antitumor effects in several cancer models including breast2, head and neck3, glioblastoma4, prostate5, colon5, and rhabdomyosarcoma6. It also promoted chemically-induced direct cardiac reprogramming of cardiac fibroblasts into cardiac myocytes.7,8
PTC 209 is a compound involved in thedown-reglation of NOTCH signaling and aids in suppressing acute leukemia cells.
