4-Aminobenzohydrazide , >98.0%(HPLC) , 5351-17-7
Synonym(s):
Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem
CAS NO.：5351-17-7
Empirical Formula: C7H9N3O
Molecular Weight: 151.17
MDL number: MFCD00007606
EINECS: 226-324-4
| Pack Size | Price | Stock | Quantity |
| 5G | RMB45.60 | In Stock |
|
| 25G | RMB184.80 | In Stock |
|
| 100G | RMB568.80 | In Stock |
|
| 500g | RMB2399.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 225-227 °C (lit.) |
| Boiling point: | 273.17°C (rough estimate) |
| Density | 1.2100 (rough estimate) |
| refractive index | 1.5860 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMF: 10 mg/ml; DMSO: 14 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml |
| pka | 13.05±0.10(Predicted) |
| form | Crystals or Powder |
| color | White or beige |
| Water Solubility | Soluble in DMSO (10 mg/ml), dilute acids, and water (partly miscible). |
| BRN | 639053 |
Description and Uses
4-Aminobenzoic acid hydrazide (4-ABAH) is an irreversible inhibitor of myeloperoxidase (MPO; IC50 = 0.3 μM). It reduces the production of hypochlorous acid (HOCl) induced by opsonized zymosan or phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils with IC50 values of 16 and 2.2 μM, respectively. 4-ABAH inhibits PMA-induced formation of neutrophil extracellular traps (NETs) in the same cells. It reduces infarct volume and the severity of neurological deficits, as well as increases survival, in a mouse model of cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO) when administered at a dose of 40 mg/kg twice per day.
4-Aminobenzoic hydrazide can be used as a reactant to synthesize:
- Acylhydrazone Schiff base ligand by condensation reaction with 2-acetylpyridine.
- Oligomeric transition metal complexes applicable in the fabrication of organic-inorganic hybrid devices with efficient electrical and photoelectrical properties.
- Oxovanadium(IV)-hydrazide complex as a potential radical scavenger.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | DG2580000 |
| HazardClass | IRRITANT |
| HS Code | 29280000 |
