4-Aminopyrazolo[3,4-<i>d</i>]pyrimidine , >97.0%(HPLC) , 2380-63-4

Synonym(s):
1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine;4-Amino-1H-pyrazolo[3,4-d]pyrimidine

CAS NO.：2380-63-4

Empirical Formula: C5H5N5

Molecular Weight: 135.13

MDL number: MFCD00005688

EINECS: 219-174-6

PRODUCT Properties

• Melting point: >325 °C(lit.)
• Boiling point: 238.81°C (rough estimate)
• Density: 1.3795 (rough estimate)
• refractive index: 1.7000 (estimate)
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: soluble in DMSO
• form: powder to crystal
• pka: 12.12±0.20(Predicted)
• color: White to Orange to Green
• Water Solubility: Insoluble in water.
• BRN: 5824
• InChIKey: LHCPRYRLDOSKHK-UHFFFAOYSA-N
• CAS DataBase Reference: 2380-63-4(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-pyrazolo[3,4-d]pyrimidin-4-amine(2380-63-4)
• EPA Substance Registry System: 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (2380-63-4)

Description and Uses

4-aminopyrazolo[3,4-d]pyrimidine (4-APP), the isomer of adenine with the five-membered ring in the pyrazole configuration, is by far the most potent inhibitor of both enzymatic reactions catalyzed by Stx1. It is also a new type of mTOR inhibitor. The 4-aminopyrazolo[3,4-d]pyrimidines, a well-characterized class of compounds for tyrosine kinase inhibition, were used as a Src inhibitor module that blocks the adenosine binding site[1-2].

4-Amino-1H-pyrazolo[3,4-d]pyrimidine decreases serum cholesterol markedly in rats.

Safety

• Symbol(GHS): GHS06,GHS07
• Signal word: Danger
• Hazard statements: H301-H315-H319-H335
• Precautionary statements: P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501-P301+P310a-P321-P501a-P261-P301+P310-P305+P351+P338
• Hazard Codes: T
• Risk Statements: 25-36/37/38-23/24/25
• Safety Statements: 26-36/37/39-45-22-36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: UR0717000
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29335990
• Toxicity: LD50 oral in rat: 141mg/kg