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A0800012

astemizole , ≥98% , 68844-77-9

Synonym(s):
1-(4-Fluorobenzyl)-2-(1-[4-methoxyphenethyl]piperidin-4-yl)aminobenzimidazole

CAS NO.:68844-77-9

Empirical Formula: C28H31FN4O

Molecular Weight: 458.57

MDL number: MFCD00153919

EINECS: 272-441-9

Pack Size Price Stock Quantity
10MG RMB74.40 In Stock
50MG RMB607.20 In Stock
250MG RMB1359.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 172.9°C
Boiling point: 627.3±65.0 °C(Predicted)
Density  1.1587 (estimate)
storage temp.  2-8°C
solubility  DMSO: >20mg/mL
pka pKa 4.85(H2O t=25.0 I=0.025) (Uncertain);8.69(H2O t=25.0 I=0.025) (Uncertain)
form  powder
color  Crystals
Water Solubility  It is soluble in DMSO (25 mg/ml ), ethanol (25 mg/ml), chloroform, methanol, and water (partly miscible).
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Description and Uses

Astemizole belongs to the second-generation class of non-sedating, non-anticholinergic antihistamines. Its non-sedating properties appear to result from its poor penetration of the blood brain barrier. As a result it shows no potentiation of CNS depressants, including alcohol. Its long half-life allows once-daily dosing.

Astemizole is used for preventing and treating severe seasonal and chronic allergic rhinitis, allergic conjunctivitis, hives, Quinke’s edema, other allergic conditions and dermatitis. Synonyms of this drug are hismanal, histazol, and others.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36
RIDADR  UN 2811 6.1 / PGII
WGK Germany  3
RTECS  DD8968000
HS Code  2933992600
Hazardous Substances Data 68844-77-9(Hazardous Substances Data)
Toxicity LD50 orl-rat: >2560 mg/kg AIPTAK 251,39,81

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