Abacavir sulfate , ≥99% , 188062-50-2

Synonym(s):
(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol sulfate;{(1S, 4R)-4-[2-Amino-6- (cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol};Abacavir Hemisulfate;Abacavir sulfate;ABC

CAS NO.：188062-50-2

Empirical Formula: C28H38N12O6S

Molecular Weight: 670.74

MDL number: MFCD04112763

EINECS: 620-488-4

PRODUCT Properties

• Melting point: 222-225°C
• storage temp.: 2-8°C
• solubility: H2O: ≥17mg/mL
• form: powder
• color: white to tan
• optical activity: [α]/D -30 to -40°, c = 0.5 in methanol
• Water Solubility: 1.68ug/L(32 ºC)
• BCS Class: 3

Description and Uses

Abacavir sulfate was first launched as Ziagen in the US for the treatment of human immunodeficiency virus (HIV) infection, in combination with other antiretroviral drugs. Abacavir is a carbocyclic nucleoside reverse transcriptase inhibitor (nRTI); it is one of the most potent anti-HIV agents to date. In vitro, Abacavir is a potent and selective inhibitor of HIV-1 and HIV-2 replication. Resistance to Abacavir develops more slowly than for other anti-HIV agents. Abacavir is highly synergistic with protease inhibitors such as Amprenavir. In clinical trials for HIV infections in adults, it produced durable suppression in viral load. Combinations with different protease inhibitors such as Nelfinavir, Saquinavir or Indinavir markedly reduced plasma viral load to undetectable levels for at least 48 weeks, and significantly raised CD4+ cell counts in adults with HIV infection, especially nRTI-naive patients. Abacavir has a good oral availability and its penetration into CSF is much more significant than for other anti-HIV drugs. The two major metabolites identified in humans were the 5'-carboxylate and the 5'-glucuronide, mainly excreted via the renal route.

Abacavir sulfate is a nucleoside reverse transcriptase inhibitor (NRTI) used for the treatment of HIV-1 infection and anti-AIDS drug. It has been used in the cytotoxicity to test its tumour promoting activity U937 cells.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H317-H319-H341-H351-H361
• Precautionary statements: P201-P202-P280-P302+P352-P305+P351+P338-P308+P313
• Hazard Codes: Xn
• Risk Statements: 63-40
• Safety Statements: 36/37
• WGK Germany: 3
• HS Code: 2933595960