Azathioprine , ≥98% , 446-86-6

Synonym(s):
6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine;6-[(1-Methyl-4-nitro-1H imidazol-5yl) sulfanyl]-7H-purine

CAS NO.：446-86-6

Empirical Formula: C9H7N7O2S

Molecular Weight: 277.26

MDL number: MFCD00069203

EINECS: 207-175-4

PRODUCT Properties

• Melting point: 243-244°C
• Boiling point: 521.0±60.0 °C(Predicted)
• Density: 1.5379 (rough estimate)
• refractive index: 1.7400 (estimate)
• storage temp.: 2-8°C
• solubility: Soluble in Dichloromethane and dimethyl sulfoxide.
• pka: 8.2(at 25℃)
• form: Solid
• color: Pale-yellow crystals from Me2CO (aq)
• Water Solubility: <0.1 g/100 mL at 23 ºC
• Merck: 14,902
• BCS Class: 4
• Stability: Stable. Incompatible with strong oxidizing agents, strong bases.
• InChIKey: LMEKQMALGUDUQG-UHFFFAOYSA-N
• CAS DataBase Reference: 446-86-6(CAS DataBase Reference)
• IARC: 1 (Vol. 26, Sup 7, 100A) 2012
• EPA Substance Registry System: Azathioprine (446-86-6)

Description and Uses

This immunosuppressive and antineoplastic drug is derived from 6-mercaptopurine. It caused occupational dermatitis in a pharmaceutical worker, reconditioner of old tablet packaging machines and in a production mechanic, working in packaging for a pharmaceutical company.

Azathioprine is an immunosuppressive purine antimetabolite. The mechanism of action of azathioprine is as a nucleic acid synthesis inhibitor. It has shown promise in treatment of alopecia areata (autoimmune hair loss), with no difference in effectiveness between genders.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H315-H319-H335-H350-H361fd
• Precautionary statements: P202-P261-P301+P312-P302+P352-P305+P351+P338-P308+P313
• Hazard Codes: Xi,T,Xn
• Risk Statements: 45-22-36/37/38-20/21/22
• Safety Statements: 53-22-26-36/37-45-36
• WGK Germany: 3
• RTECS: UO8925000
• HazardClass: IRRITANT
• HS Code: 29339900
• Hazardous Substances Data: 446-86-6(Hazardous Substances Data)
• Toxicity: LD50 orl-rat: 535 mg/kg NIIRDN 6,3,82