Home Categories API Amiodarone hydrochloride
A0787112

Amiodarone hydrochloride , ≥98% , 19774-82-4

Synonym(s):
(2-Butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride;2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride

CAS NO.:19774-82-4

Empirical Formula: C25H29I2NO3.ClH

Molecular Weight: 681.77

MDL number: MFCD00069204

EINECS: 243-293-2

Pack Size Price Stock Quantity
1G RMB167.20 In Stock
5G RMB620.80 In Stock
25G RMB2042.40 In Stock
100G RMB6719.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 154-158°C
Flash point: 9℃
storage temp.  2-8°C
solubility  Soluble in chloroform, methanol.
pka pKa (25°C) 6.56 ±0.06
form  Solid
color  White
λmax 242nm(MeOH)(lit.)
Merck  14,482
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
CAS DataBase Reference 19774-82-4(CAS DataBase Reference)

Description and Uses

Amiodarone HCl (19774-82-4) is a nonselective ion channel blocker. Class III antiarrhythmic.1 Induces cytochrome c release and induces apoptosis.2 An alkalizing agent which stimulates progranulin (GRN) production and prevents GRN-dependent neurodegeneration.3 Induces autophagy and suppresses hepatocellular carcinoma tumorigenesis via autophagy-mediated MIR224 degradation in vitro and in vivo.4

Amiodarone induces an immediate influx of Ca2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.

Safety

Symbol(GHS) 
GHS07,GHS08,GHS09
Signal word  Warning
Hazard statements  H312+H332-H315-H319-H361d-H373-H410
Precautionary statements  P260-P280-P305+P351+P338
Hazard Codes  Xn,T,F
Risk Statements  20/21/22-39/23/24/25-23/24/25-11
Safety Statements  36-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  OB1361000
HS Code  29322090
Hazardous Substances Data 19774-82-4(Hazardous Substances Data)
Toxicity dog,LD50,intravenous,5gm/kg (5000mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.

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