Amiodarone hydrochloride , ≥98% , 19774-82-4

Synonym(s):
(2-Butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride;2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride

CAS NO.：19774-82-4

Empirical Formula: C25H29I2NO3.ClH

Molecular Weight: 681.77

MDL number: MFCD00069204

EINECS: 243-293-2

PRODUCT Properties

• Melting point: 154-158°C
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: Soluble in chloroform, methanol.
• pka: pKa (25°C) 6.56 ±0.06
• form: Solid
• color: White
• λmax: 242nm(MeOH)(lit.)
• Merck: 14,482
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

Description and Uses

Amiodarone HCl (19774-82-4) is a nonselective ion channel blocker. Class III antiarrhythmic.1 Induces cytochrome c release and induces apoptosis.2 An alkalizing agent which stimulates progranulin (GRN) production and prevents GRN-dependent neurodegeneration.3 Induces autophagy and suppresses hepatocellular carcinoma tumorigenesis via autophagy-mediated MIR224 degradation in vitro and in vivo.4

Amiodarone induces an immediate influx of Ca2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Warning
• Hazard statements: H312+H332-H315-H319-H361d-H373-H410
• Precautionary statements: P260-P280-P305+P351+P338
• Hazard Codes: Xn,T,F
• Risk Statements: 20/21/22-39/23/24/25-23/24/25-11
• Safety Statements: 36-45-36/37-16-7
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: OB1361000
• HS Code: 29322090
• Toxicity: dog,LD50,intravenous,5gm/kg (5000mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.