Articaine HCl , ≥99% , 23964-57-0

Synonym(s):
4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester hydrochloride;Articaine hydrochloride;Carticaine chlorhydrate;Carticaine hydrochloride

CAS NO.：23964-57-0

Empirical Formula: C13H20N2O3S.ClH

Molecular Weight: 320.839

MDL number: MFCD00190157

EINECS: 245-957-7

PRODUCT Properties

• Melting point: 177-178°
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• solubility: H2O: soluble20mg/mL, clear
• form: powder
• color: white to beige
• Stability: Hygroscopic
• InChI: InChI=1S/C13H20N2O3S.ClH/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4;/h7,9,14H,5-6H2,1-4H3,(H,15,16);1H
• InChIKey: GDWDBGSWGNEMGJ-UHFFFAOYSA-N
• SMILES: C1(NC(=O)C(C)NCCC)C(C)=CSC=1C(=O)OC.Cl

Description and Uses

Articaine hydrochloride is a thiophene-containing local anesthetic pharmacologically similar to mepivacaine. Most local anesthetics act by abolishing voltage-gated sodium channel currents indiscriminately in all populations of neurons. Articaine is an amide local anesthetic most commonly used in dentistry. It possesses a unique ester side chain that is metabolized rapidly by circulating esterases. Articaine is reported to modify cardiac action potentials and ion currents only at concentrations higher than the therapeutic range needed to inhibit voltage-gated sodium channels.

Articaine hydrochloride, belonging to the group of amide anesthetics, is a local anesthetic with a short duration of action. It is utilized for regional anesthesia in day-case surgeries such as arthroscopy, hand and foot surgery, and dentistry.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 2934990002
• Toxicity: LD50 i.v. in mice: 37 mg/kg (Muschaweck, Rippel)