Azelastine HCl , ≥98%(HPLC) , 79307-93-0

Synonym(s):
4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one hydrochloride;Astelin;Azelastine hydrochloride;Optivar

CAS NO.：79307-93-0

Empirical Formula: C22H25Cl2N3O

Molecular Weight: 418.36

MDL number: MFCD00242783

EINECS: 620-469-0

PRODUCT Properties

• Melting point: 225--2290C
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: DMSO: >10mg/mL
• form: powder
• color: white to off-white
• Merck: 14,906
• Stability: Incompatible with strong oxidizing agents.
• InChI: InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H
• InChIKey: YEJAJYAHJQIWNU-UHFFFAOYSA-N
• SMILES: C1(=O)C2=C(C=CC=C2)C(CC2=CC=C(Cl)C=C2)=NN1C1CCCN(C)CC1.[H]Cl

Description and Uses

Azelastine hydrochloride is an orally effective antihistamine useful in the treatment of asthma and nasal allergy. It appears to inhibit release of histamine, in addition to antagonizing its action.

Orally active H1-hystamine receptor antagonist. Antihistaminic

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn
• Risk Statements: 22
• RTECS: TH9203900
• HS Code: 2933992600
• Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 36.5, 35.5, 26.9, 30.3 i.v.; 56.4, 42.8, 43.2, 46.6 i.p.; 63.0, 54.2, 66.5, 59.6 s.c.; 124, 139, 310, 417 orally (Zechel)