α-Amine-ω-propionic acid tetraethylene glycol , 98% , 663921-15-1

Synonym(s):
Amino-PEG₄-acid;Amino-PEG-acid;CA(PEG)₄;Carboxy-PEG₄-amine;NH₂-PEG₄-COOH

CAS NO.：663921-15-1

Empirical Formula: C11H23NO6

Molecular Weight: 265.3

MDL number: MFCD11041129

EINECS: 828-940-4

PRODUCT Properties

• Boiling point: 409.6±40.0 °C(Predicted)
• Density: 1.134±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• pka: 4.28±0.10(Predicted)
• form: powder
• color: White
• InChI: InChI=1S/C11H23NO6/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h1-10,12H2,(H,13,14)
• InChIKey: DKUZHSDZSMQOGQ-UHFFFAOYSA-N
• SMILES: C(O)(=O)CCOCCOCCOCCOCCN

Description and Uses

Amino-PEG4-acid is a very popular PEG linker. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond, long PEG spacer increases reagent's solubility in aqueous media.

H2N-Dpeg(4)-COOH, can be used in optical imaging of integrin αvβ3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers. Integrin αvβ3 plays great roles in tumor angiogenesis, invasion, and metastasis.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P280-P301+P312-P261
• HS Code: 2942000090