YM90709 , ≥99%(HPLC) , 163769-88-8

CAS NO.：163769-88-8

Empirical Formula: C22H21N3O2

Molecular Weight: 359.42

MDL number: MFCD00354370

PRODUCT Properties

• Boiling point: 579.6±50.0 °C(Predicted)
• Density: 1.28±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,Room Temperature
• solubility: DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml
• form: A crystalline solid
• pka: 2.74±0.40(Predicted)
• color: Brown to orange

Description and Uses

YM-90709 is a competitive antagonist of the interleukin-5 (IL-5) receptor that has IC₅₀ values of 1 and 0.57 μM for peripheral human eosinophils and eosinophilic HL-60 clone 15 cells, respectively, in a radioligand binding assay. It inhibits IL-5-induced eosinophil survival (IC₅₀ = 0.45 μM) and JAK2 phosphorylation in vitro. YM-90709 inhibits eosinophil and lymphocyte infiltration (ED₅₀s = 0.32 and 0.12 mg/kg, respectively) into the brochoalveolar lavage fluid (BALF) of rats and eosinophil infiltration (ED₅₀ = 0.05 mg/kg) into the BALF of mice in models of airway inflammation.

YM 90709, is an interleukin-5 receptor antagonist.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P330-P501