SR-9009 , 98% , 1379686-30-2

Synonym(s):
Ethyl-3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate;REV-ERB Agonist II, SR9009 - Calbiochem

CAS NO.：1379686-30-2

Empirical Formula: C20H24ClN3O4S

Molecular Weight: 437.94

MDL number:

EINECS: 1592732-453-0

PRODUCT Properties

• Melting point: 79-81°C
• Boiling point: 547.2±45.0 °C(Predicted)
• Density: 1.327±0.06 g/cm3(Predicted)
• storage temp.: -20°
• solubility: Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 20 mg/ml).
• form: solid
• pka: 6.12±0.50(Predicted)
• color: Tan
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
• InChI: InChI=1S/C20H24ClN3O4S/c1-2-28-20(25)23-10-9-16(13-23)12-22(11-15-3-5-17(21)6-4-15)14-18-7-8-19(29-18)24(26)27/h3-8,16H,2,9-14H2,1H3
• InChIKey: MMJJNHOIVCGAAP-UHFFFAOYSA-N
• SMILES: N1(C(OCC)=O)CCC(CN(CC2=CC=C(Cl)C=C2)CC2SC([N+]([O-])=O)=CC=2)C1

Description and Uses

SR-9009 is an agonist at nuclear receptor Rev-ErbA. Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model. SR-9009 suppresses atherosclerosis in a mouse model. Specifically lethal to cancer cells and oncogene-induced senescent cells with no effect on the viability of normal cells or tissues. Disrupts pain associated with osteoarthritis by reducing BMAL1 expression in bmal1f/fNav1.8CreERT mice.

SR 9009 is a synthetic REV-ERB agonist that regulates circadian behavior and metabolism; has potential use in the treatment of sleep disorders and metabolic diseases. It is a lead compound for a new class of cancer drugs associated with the body’s circadian clock.