Gracillin , ≥95% , 19083-00-2

CAS NO.：19083-00-2

Empirical Formula: C45H72O17

Molecular Weight: 885.04

MDL number: MFCD28978176

PRODUCT Properties

• Melting point: 290-293℃ (DEC.)
• Density: 1.42
• storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
• solubility: Soluble in DMSO, methanol and pyridine
• form: powder
• pka: 12.78±0.70(Predicted)
• color: White

Description and Uses

Gracillin is a steroidal saponin that has been found in C. speciosus and has diverse biological activities. It reduces cell growth in a panel of 58 leukemia, non-small cell lung, colon, CNS, prostate, melanoma, ovarian, renal, and breast cancer cell lines (GI₅₀s = 0.58-2.44 μM). Gracillin reduces growth of fish Ich parasite (I. multifiliis) theronts (EC₅₀ = 0.53 mg/L) and induces 100 and 92.5% mortality of I. multifiliis protomonts and encysted tomonts, respectively, when used at a concentration of 0.8 mg/L. It decreases the number of I. multifiliis-infected goldfish by approximately 75% when used at a concentration of 1 mg/L in tank water. Gracillin (100 mg/kg) reduces ear edema induced by arachidonic acid in mice.

Gracillin is a steroidal glycoside from the rhizomes of the family Dioscoreaceae with potential anti-proliferative effects.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319
• Precautionary statements: P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
• HS Code: 29329990