A0654712
Amyloid β-Protein Fragment 25-35 , 97% , 131602-53-4
CAS NO.：131602-53-4
Empirical Formula: C45H81N13O14S
Molecular Weight: 1060.27
MDL number: MFCD00133076
| Pack Size | Price | Stock | Quantity |
| 1MG | RMB229.60 | In Stock |
|
| 2MG | RMB399.20 | In Stock |
|
| 5MG | RMB607.20 | In Stock |
|
| 10mg | RMB1026.40 | In Stock |
|
| 25mg | RMB1919.20 | In Stock |
|
| 100mg | RMB5439.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 1517.3±65.0 °C(Predicted) |
| Density | 1.248±0.06 g/cm3(Predicted) |
| RTECS | BU7435200 |
| storage temp. | -20°C |
| solubility | insoluble in EtOH; insoluble in H2O; ≥106 mg/mL in DMSO |
| form | Lyophilized. |
| pka | 3.24±0.10(Predicted) |
| color | Lyophilized White |
| Water Solubility | Soluble in water. |
| Sequence | H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH |
| InChIKey | WIHBNMPFWRHGDF-SLVFWPMISA-N |
Description and Uses
Beta-amyloid protein (Abeta), a major component of senile plaques of Alzheimer's disease (AD) in the brain, causes elevation of the intracellular free Ca2+ level and the production of robust free radicals. Beta-amyloid 25-35 induced apoptosis, characterized by decreased cell viability, neuronal DNA condensation, and fragmentation, is associated with an increase in intracellular free Ca2+ level, the accumulation of reactive oxygen species (ROS), and the activation of caspase-3. All of these effects induced by beta-amyloid 25-35 are reversed by genistein.
Amyloid β-Protein Fragment 25-35 has been used:
- to induce neurotoxicity in cortical cultures
- to induce Alzheimer′s disease in rat model
- to induce apoptosis in mesenchymal stem cells (MSCs)
Safety
| WGK Germany | 3 |
| HS Code | 2930909899 |
