3-Amino-1-propanesulfonic acid , 97% , 3687-18-1

Synonym(s):
3-Amino-1-propanesulfonic acid;3APS;Acamprosate Calcium Impurity A (PhEur);Homotaurine;Tramiprosate

CAS NO.：3687-18-1

Empirical Formula: C3H9NO3S

Molecular Weight: 139.17

MDL number: MFCD00008225

EINECS: 222-977-4

PRODUCT Properties

• Melting point: 293 °C (dec.)(lit.)
• Density: 1.202 (estimate)
• refractive index: 1.5130 (estimate)
• storage temp.: 2-8°C
• solubility: Water (Slightly)
• form: Crystalline Powder
• pka: 1.06±0.50(Predicted)
• color: White to slightly blue
• LogP: -4.555
• CAS DataBase Reference: 3687-18-1(CAS DataBase Reference)

Description and Uses

Homotaurine (also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS) is a natural sulfonic acid found in seaweed. Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation. Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates. It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.

3-Amino-1-propanesulfonic acid is a Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA). It is an intermediate in the synthesis of acamprosate. acamprosate is an alcohol addiction treatment commonly used to reduce urges to drink and help people in recovery remain sober.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 1
• HS Code: 29049090