Artemether , Analysis of standard products, ≥98% , 71963-77-4
Synonym(s):
Dihydroartemisinin methyl ether;Dihydroqinghaosu methyl ether;SM-224
CAS NO.：71963-77-4
Empirical Formula: C16H26O5
Molecular Weight: 298.37
MDL number: MFCD00866205
EINECS: 663-549-0
| Pack Size | Price | Stock | Quantity |
| 20MG | RMB174.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 86-88°C |
| alpha | D19.5 +171° (c = 2.59 in CHCl3) |
| Boiling point: | 359.79°C (rough estimate) |
| Density | 1.0733 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| storage temp. | room temp |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| color | off-white to light brown |
| optical activity | [α]/D +155 to +175°, c = 0.5 in methanol |
| Merck | 14,815 |
| InChI | InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1 |
| InChIKey | SXYIRMFQILZOAM-HVNFFKDJSA-N |
| SMILES | O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)[C@@H](OC)O4)O1 |
Description and Uses
Artemether is an antiparasitic compound and a derivative of artemisinin . It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria.
Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.
Safety
| Symbol(GHS) |   GHS02,GHS07 |
| Signal word | Danger |
| Hazard statements | H242-H302 |
| Precautionary statements | P210-P235-P280-P301+P312-P370+P378-P410 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | KD4165000 |
| HS Code | 29329930 |
| Hazardous Substances Data | 71963-77-4(Hazardous Substances Data) |
| Toxicity | LD50 i.m. in mice: 263 mg/kg (China Cooperative Research Group on Qinghaosu) |
