Home Categories Biochemical Engineering Aprotinin from bovine lung
A0637012

Aprotinin from bovine lung , 3-8TIU/mg , 9087-70-1

Synonym(s):
Aprotinin from bovine lung;Trasylol;Trypsin inhibitor (basic);trypsin inhibitor, pancreas type (bpti);trypsin-kallikrein inhibitor

CAS NO.:9087-70-1

Empirical Formula: C284H432N84O78R2S7

Molecular Weight: 6495.44

MDL number: MFCD00130541

EINECS: 232-994-9

Pack Size Price Stock Quantity
5MG RMB68.80 In Stock
25MG RMB171.20 In Stock
50mg RMB320.00 In Stock
100MG RMB584.00 In Stock
250mg RMB1340.00 In Stock
500MG RMB2401.60 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: >234oC (dec.)
storage temp.  2-8°C
solubility  glycerol: soluble3mg/mL, clear, colorless (equilibration buffer containing 5% glycerol)
form  lyophilized powder
color  white
Water Solubility  Freely soluble in water and in aqueous buffers of low ionic strength.
Merck  13,761
Sequence H-Pro-Asp-Phe-Cys-Leu-Glu-Pro-Pro-Tyr-Thr-Gly-Pro-Cys-Lys-Ala-Arg-Ile-Ile-Arg-Tyr-Phe-Tyr-Asn-Ala-Lys-Ala-Gly-Leu-Cys-Gln-Thr-Phe-Val-Tyr-Gly-Gly-Cys-Arg-Ala-Lys-Arg-Asn-Asn-Phe-Lys-Ser-Ala-Glu-Asp-Cys-Met-Arg-Thr-Cys-Gly-Gly-Ala-OH
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey RWLBZZCCAZDWSE-BNRYNCRGNA-N

Description and Uses

Aprotinin is a reversible inhibitor of serine proteases such as trypsin (Ki = 0.06 pM), chymotrypsin (Ki = 9.5 nM), and kallikrein (Ki = 0.8 nM). It is a much weaker inhibitor of thrombin (Ki = 0.1-0.8 mM) and trypsinogen (Ki = 2 μM). Aprotinin also competitively inhibits nNOS and iNOS with Ki values of 50 and 78 μM, respectively. Aprotinin is widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.

A potent protease inhibitor.Aprotinin acts as a reversible serine protease blocking and a binding agent. It is widely employed as an inhibitor of trypsin. It is also used as a proteolytic inhibitor in radioimmunoassays of polypeptide hormones. It is involved in the purification of urokinase, trypsin, and chymotrypsin on immobilized aprotinin. Further, it is used in the quantification of kallikrein activity in mixtures of esterases and proteases.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
Hazard Codes  Xn,Xi
Risk Statements  42/43-36/37/38-20/21/22
Safety Statements  22-45-36/37-36-26
WGK Germany  1
RTECS  YN5080000
10-21
HS Code  35040000
Toxicity LD50 i.v. in mice: 2500000 kallikrein inhibitor units/kg (Trautschold)

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