PRODUCT Properties
| Melting point: | 91°C |
| Boiling point: | 348.6°C (rough estimate) |
| Density | 1.1200 |
| vapor pressure | 1.3 x 10-3 Pa (20 °C) |
| refractive index | 1.5080 (estimate) |
| Flash point: | -18 °C |
| storage temp. | 2-8°C |
| solubility | Chloroform: slightly; Methanol: slightly |
| pka | 12.28±0.46(Predicted) |
| form | Minute Crystals |
| color | White to off-white |
| Water Solubility | Slightly soluble. 0.2 g/100 mL |
| Merck | 13,7929 |
| BRN | 1879891 |
| Exposure limits | OSHA TWA: 0.5 mg/m3; ACGIH TLV: TWA 0.5 mg/m3. |
| CAS DataBase Reference | 114-26-1 |
| NIST Chemistry Reference | 2-Isopropoxyphenyl N-methylcarbamate(114-26-1) |
| EPA Substance Registry System | Propoxur (114-26-1) |
Description and Uses
Propoxur is a carbamate insecticide and an inhibitor of acetylcholinesterase. It is lethal to German cockroaches (B. germanica) with LD50 values of 2.45, 4.73, and 1.06 μg per insect for newly emerged males, newly emerged females, and 4-week-old nymphs, respectively. Propoxur induces lactate dehydrogenase (LDH) release from and inhibits the growth of flounder gill cells (IC50s = 86.59 and 89.96 μg/ml, respectively) via induction of necrosis. It also induces yolk sac and pericardial edema in zebrafish embryos when used at concentrations of 100 and 200 μg/ml. Propoxur (8.3 mg/kg) inhibits rat blood and brain cholinesterase, decreases ambulation and rearing in an open field test, and increases latency to escape foot shock after an audio stimulus in the two-way active avoidance box in rats.
Propoxur is a non-systematic carbamate insecticide. Propoxur is used against a wide range of insects such as fleas, mosquitoes, ants, gypsy moths, and other agricultural pests. Propoxur functions by r eversibly inactivating the enzyme acetylcholinesterase in insects.
Safety
| Symbol(GHS) |   GHS06,GHS09 |
| Signal word | Danger |
| Hazard statements | H300+H330-H311-H410 |
| Precautionary statements | P260-P264-P273-P280-P302+P352+P312-P304+P340+P310 |
| Hazard Codes | T;N,N,T,Xn,F |
| Risk Statements | 25-50/53-67-65-38-11 |
| Safety Statements | 37-45-60-61-62 |
| RIDADR | UN 2811/2588 |
| OEB | C |
| OEL | TWA: 0.5 mg/m3 |
| WGK Germany | 3 |
| RTECS | FC3150000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Hazardous Substances Data | 114-26-1(Hazardous Substances Data) |
| Toxicity | LD50 orally in male, female rats: 83, 86 mg/kg (Gaines) |
