Home Categories Organic Chemistry (±)-Epichlorohydrin
A0405156

(±)-Epichlorohydrin , 1000mg/L, solvent: dichloromethane

Synonym(s):
(±)-2-(Chloromethyl)oxirane;1-Chloro-2,3-epoxypropane

CAS NO.:

Empirical Formula: C3H5ClO

Molecular Weight: 92.52

MDL number: MFCD00005132

EINECS: 203-439-8

Update time: 2022-07-08

PRODUCT Properties

Melting point: -57 °C
alpha  -1~+1°(D/20℃)(c=1,CH3OH)
Boiling point: 115-117 °C(lit.)
Density  1.183 g/mL at 25 °C(lit.)
vapor density  3.2 (vs air)
vapor pressure  13.8 mm Hg ( 21.1 °C)
refractive index  n20/D 1.438(lit.)
Flash point: 93 °F
storage temp.  Store below +30°C.
solubility  65.9g/l
form  Liquid
color  APHA: ≤20
Specific Gravity 1.183 (20/4℃)
Odor Pungent, garlic; sweet, pungent; like chloroform.
explosive limit 3.8-21%(V)
Water Solubility  6 g/100 mL (10 ºC)
FreezingPoint  -57.2℃
Merck  14,3611
BRN  79785
Henry's Law Constant 3.42(x 10-5 atm?m3/mol) at 25 °C (static headspace-GC, Welke et al., 1998)
Exposure limits TLV-TWA(skin) 8 mg/m3 (2 ppm) (ACGIH); STEL (15 min) 19 mg/m3 (5 ppm) (NIOSH).
Dielectric constant 22.9(20℃)
Stability: Unstable. Flammable - note wide explosion limits and low flash point.
LogP 0.45 at 20℃

Description and Uses

Epoxy resins of the bisphenol A type are synthesized from epichlorhydrin and bisphenol A. This leads to bisphenol-A diglycidyl ether, which is the monomer of bisphenol-A-based epoxy resins. Sensitization to epichlorhydrin occurs mainly in workers in the epoxy-resin industry. Sensitization in individuals not working at epoxy resin plants is rare. It has however been described to occur after contact with a soil fumigant, due to solvent cement and in a worker in a pharmaceutical plant, in a division for drug synthesis. Epichlorhydrin was used for the production of both drugs propranolol and oxprenolol.

Commercially the most important use is production of glycerine. Large volumes are consumed in nonglycerine areas, which largely consist of the various epoxy resins. It has use as a solvent and in the production of epichlorohydrin rubber.

Safety

Symbol(GHS) 
GHS02,GHS05,GHS06,GHS08
Signal word  Danger
Hazard statements  H226-H301+H311+H331-H314-H317-H350
Precautionary statements  P201-P210-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T
Risk Statements  45-10-23/24/25-34-43
Safety Statements  53-45
RIDADR  UN 2023 6.1/PG 2
WGK Germany  3
RTECS  TX4900000
Autoignition Temperature 779 °F
TSCA  Yes
HS Code  2910 30 00
HazardClass  6.1
PackingGroup  II
Toxicity LD50 orally in rats: 0.09 g/kg (Smyth, Carpenter)
IDLA 75 ppm

RELATED PRODUCTS